The College of Health Sciences traces its humble beginnings to the College of Nursing of the Mariano Marcos Memorial College of Science and Technology (MMMCST).  It was opened on June 20, 1976 by virtue of Board Resolution No. 140, s. 1976 which authorized the offering of the Bachelor of Science in Nursing program effective Academic Year (AY) 1976-1977 with Dr. Deborah R. Abara as the first dean.

On January 6, 1978, the then MMMCST in Batac and the Northern Luzon State College (NLSC) in Laoag were merged to establish the Mariano Marcos State University by virtue of Presidential Decree 1279 signed by Pres. Ferdinand E. Marcos.  Together with these two colleges, the college departments of the Ilocos Norte College of Agriculture (INAC) and the Ilocos Norte College of Arts and Trades (INCAT) were integrated into the University.  Letter of Implementation (LOI) No. 73 issued by Pres. Marcos on Sept. 28, 1978 directed the transfer of the Mariano Marcos Memorial Hospital School of Nursing in the Mariano Marcos Memorial Regional and Medical Center as a unit of MMSU.    

In 1993, the college became the Institute of Health Sciences (IHS). Sensitive to the needs and complexities of the times, the administration decided to propose the offering of the Bachelor of Science in Physical Therapy and the Bachelor of Science in Pharmacy degree programs in March 1993 which was approved during the 26th Regular Meeting of the MMSU Board of Regents on May 7, 1993 at the Department of Education, Culture and Sports (DECS), Manila through Board Resolution No. 183A, s. 1993 starting on the First Semester, AY 1993-1994. In 1995, IHS was changed to its present name, the College of Health Sciences by virtue of Board Resolution No. 263, s. 1995 during the incumbency of Dr. Elias L. Calacal as University president.

Currently, the college and its three programs are renowned nationally for their excellence producing some of the top-notch professionals globally along the fields of nursing, pharmacy, and physical therapy; a valuable contributor to MMSU's vision of becoming a premiere Philippine university by 2028.